NovaBioX® H-HPC
(Premium Cellulose Ether for Advanced Coatings)
Chemical Name: Hydroxypropyl cellulose
CAS No.: 9004-64-2
MF: (C3H7O)~n~
Hydroxypropyl cellulose is a water-soluble, non-ionic cellulose ether used extensively as a binder, film former, and thickening agent in pharmaceuticals, food, and cosmetics.
According to Chinese Pharmacopoeia 2020 Edition (Part IV).
Registration No.: F20180000537
Item | Specification |
Hydroxypropoxy content,Wt% | 53.4-80.5 |
Loss on drying,Wt% | ≤5.0 |
pH | 5.0-8.0 |
Residue on ignition,Wt% | ≤0.8 |
Arsenic, ppm | ＜2 |
Heavy metals, ppm | ≤10 |
Chlorides,Wt% | ≤0.15 |
Sulfur dioxide,Wt% | ≤0.6 |
Toluene,Wt% | ≤0.089 |
Isopropanol,Wt% | ≤0.5 |
Viscosity Specifications：
Grade | Concentration, % | Temperature, °C | Viscosity, mPa·s |
RT-G | 2 | 25 ± 0.2 | 150–400 |
RT-J | 5 | 25 ± 0.2 | 150–400 |
RT-L | 5 | 25 ± 0.2 | 75–150 |
RT-E | 10 | 25 ± 0.2 | 300–700 |
RT-M | 2 | 25 ± 0.2 | 4000–6500 |
RT-H | 2 | 25 ± 0.2 | 20000–50000 |
RT-LM | 2 | 25 ± 0.2 | 1000–3000 |
As a binder: In the pharmaceutical field, this product is mainly used as a binder, e.g., for tablets, granules, and pellet binders. The typical dosage is 1–5% of the drug weight. Choosing RT-L or RT-J type can increase tablet stability and hardness, with dissolution time superior to tablets using other binders.
As a film coating material for tablets: H-HPC has excellent film-forming properties, producing tough and elastic films. It can be used with plasticizers. Its low equilibrium moisture content allows further improvement in film stability when mixed with other excipients. RT-L type is generally selected.
As a thickener for coatings: Additive for coatings and stabilizer for emulsions. RT-M type is generally selected.
As a matrix material for sustained-release tablets: Sustained-release pellets and bilayer sustained-release tablets. RT-M type is generally selected.
As a gelling agent for drug combinations and as an ointment base: RT-M type is generally selected.
Due to its excellent film-forming properties, H-HPC can be dissolved in organic solvents to produce films with good tensile strength, serving as a carrier for local therapeutic drugs in the human body.
Soluble in water or various polar organic solvents at room temperature, e.g., anhydrous methanol, ethanol, isopropanol, propylene glycol, dichloromethane; also soluble in acetone, chloroform, benzene, etc. H-HPC does not aggregate in organic solvent solutions, even at elevated temperatures. It is almost insoluble in hot water.
H-HPC is a good thermoplastic material with a plastic temperature range of 130–150 °C. Thermoplastic products retain their water solubility. It has excellent film-forming properties, producing very tough films with good gloss and sufficient elasticity.
Very low ash content gives this product good binding properties. As an emulsion adhesive, it is very stable and has good dispersibility. H-HPC itself is non-toxic and physiologically harmless. H-HPC is chemically inert and rarely reacts with other substances.
The substituents are relatively uniform and sufficient, giving H-HPC strong resistance to yellowing.
Low equilibrium moisture content; does not become sticky under high-temperature conditions.
Due to its nonionic nature, this product does not aggregate in acidic solutions and exhibits excellent stability over a wide pH range.
Aqueous solutions of H-HPC can form positive-oriented liquid crystals.
H-HPC aqueous solutions exhibit surface-active properties.
The viscosity of its aqueous solution decreases with increasing temperature, undergoing reversible gelation and dissolution processes.
Additionally, H-HPC possesses binding, emulsifying, foaming, suspending, and thickening abilities.
Physicochemical Properties:
Appearance: White or off-white powder or granules; hygroscopic when dry.
Particle size: Not less than 99% through 20 mesh, not less than 95% through 30 mesh.
Bulk density: 0.5–0.6 g/ml; specific gravity 1.2224.
Thermal stability:
Discoloration temperature: 195–210 °C
Carbonization temperature: 260–275 °C
Softening temperature: 130 °C
Dissolves in water below 40 °C, forming a clear and transparent solution below 38 °C.
Dissolution in water:
Slowly add H-HPC into vigorously stirred water until completely dissolved. Rapid addition of the entire amount will make dissolution difficult.
Heat 20–30% of the required water to above 60 °C, slowly add H-HPC with thorough stirring. After all H-HPC has been added, add the remaining 70–80% of water to achieve complete dissolution.
Dissolution in organic solvents:
Slowly add H-HPC into the organic solvent with thorough stirring. Adding all at once makes dissolution very difficult.
Commonly used organic solvents:
Glacial acetic acid, acetone; water (9:1), benzene; methanol (1:1), chloroform, cyclohexanone, ethanol, formic acid (88%), glycerol; water (3:7), 95% isopropanol, methanol, dichloromethane; methanol (9:1), ethylene glycol,etc.
25kgs/drum with polyethylene film bags.
Keep tightly sealed, avoid sun and rain, protect from moisture, and avoid contact with acids and alkalis.
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