In the high-tech fields of pharmaceuticals and electronics, the issue of metal ion residues in final products is garnering increasing concern. The removal of heavy metals, purification of electronic-grade reagents, and recovery of precious metals from solutions are critical challenges faced by many enterprises.
To address these challenges, we have developed the Agesin® SPA-MetSil series—a new generation of highly efficient, environmentally friendly metal scavengers. These products offer broad applicability, excellent tolerance to temperature and pH variations, and superior metal adsorption performance in both aqueous and organic phases.
Pharmaceuticals
Electronic-grade Reagents
Display Materials
Precious Metal Recovery
Other High-value-added Chemicals
Our functionalized silica gels work by selectively chelating metal ions. The functional groups on the silica surface form stable complexes with specific metals.
After adsorption at room temperature or with heating, the pure compound is obtained simply by filtration and washing, leaving the metal ions bound to the scavenger.
The chart below illustrates the wide range of metals (blue part)effectively removed by our SPA-MetSil series, capable of reducing concentrations to ppb levels in critical applications.
The Agesin® SPA-MetSil series includes various products functionalized for specific metal selectivity.
No. | Agesin SPA-MetSil | Remarks | Effective Metals Removed | Capacitymmol/g | Solvent Compatibility | Storage | Usage Method |
1 | SPA-MetSil-SH (Main Product) | SPA-MetSil-SH is a widely applicable metal ion scavenger, suitable for removing metal ions from various pharmaceutical and electronic products. | Ag, Hg, Os, Pd, Pd²⁺, Cu, Ir, Rh, Sn | 0.9–1.2 | Water or organic solvents | Keep dry | Stirring adsorption / Column chromatography
Electronics: dosage 0.5%–1%
Metal ion adsorption and recovery: 2–4 times the calculated amount |
2 | SPA-MetSil-DA | SPA-MetSil amino-modified silica is grafted via a coupling agent and functionalized with amino groups. It is widely used and shows good performance in removing metal ions from TFT mixed crystals. | Cr, Pr, Pd, Pd²⁺, Cd, Co, Cu, Fe, Hg, Pb, Zn, Ni | 0.7–1.0 | |||
3 | SPA-MetSil-Triamine | Cr, Pb, Pd²⁺, Pt, Co, Cu, Fe, Hg, Ru, Zn | 0.7-1.0 | ||||
4 | SPA-MetSil-Amine | Cd, Cr, Pr, Rh | 0.9-1.2 |
Advantage | Description |
Eco-Friendly | Non-polluting to the final product. |
High Purity | Manufactured under strict quality control for defect-free, high-purity products. |
High Selectivity | Selectively adsorbs target metal impurities. |
Broad Applicability | Effective for various metal species and oxidation states. |
Fast Kinetics | Rapid metal capture at room temperature. |
High Efficiency | Low consumption per gram of metal recovered; reduced solvent usage. |
Solvent Compatibility | Stable in various organic solvents and aqueous solutions (pH 2-12). |
Excellent Stability | High thermal and mechanical stability; suitable for vigorous stirring and high temperatures. |
Easy Operation | Simple application via column chromatography or stir-and-filter methods. |
Supply Assurance | Short lead time (e.g., 100 kg in 7 days); 200-300 kg standby inventory; flexible packaging. |
Cost-Effective | Priced >20% lower than competitive products with comparable performance. |
Test: A self-prepared metal ion solution was treated with 2% of both SPA-MetSil and an imported brand (SiliaMets™) silica gel, stirred for 3 hours at room temperature, and filtered.
Compared with imported modified silica gel | |
More effective | Co, Cr, Pb, Zn |
Less effective | Fe, Cu, Al, Ga |
Neither shows removal effect: | Na, K, Li, Mg, Mn, Ca |
Overall effect: | SPA-MetSil-SH modified silica gel performs better. |
Compared with imported modified silica gel | |
More effective | Cu, Co, Cr, Pb, Zn |
Less effective | Fe, Al, Ga |
Neither shows removal effect: | Na, K, Li, Mg, Mn, Ca |
Overall effect: | SPA-MetSil-SH modified silica gel performs better. |
Conclusion: The metal ion concentration in the solution was measured after treatment. The data demonstrates that SPA-MetSil's overall metal adsorption performance is comparable to, or better than, the imported product.
Test: A pharmaceutical intermediate was dissolved in dichloromethane and treated with 10% SPA-MetSil silica gel by stirring for 3 hours at room temperature. The mother liquor was concentrated and analyzed after filtration.
Conclusion: The test showed a significant reduction in key metal impurities (Na, Mg, Ca, Fe), from tens of thousands of ppb levels down to tens or hundreds of ppb levels.
Test: 20g of mixed crystals were taken. 1% of imported SiliaMets modified silica gel and 1% of SPA-MetSil modified silica gel were added respectively. After stirring for 2 hours and allowing to stand, the product was taken to test changes in ions. The test items were: resistivity, ion concentration, VHR.
Resistivity Data
Mixed Crystals | 1 | 2 |
Initial Resistivity | 3.59E+14 | 4.58E+14 |
After SiliaMets Adsorption | 6.96E+14 | 7.74E+14 |
After Agesin SPA-MetSil Adsorption | 5.60E+14 | 8.37E+14 |
Ion Concentration & VHR Data
Mixed Crystal Material | Competitor SiliaMets Adsorption | SPA-MetSil Modified Silica Gel Adsorption | ||||||||||
1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | |
VHR | 99.19% | 99.16% | 98.96% | 98.94% | 99.25% | 99.22% | 99.24% | 99.25% | 99.35% | 99.28% | 99.24% | 99.19% |
Ion Concentration | 38.53 | 42.62 | 45.67 | 42.81 | 14.84 | 20.56 | 34.65 | 36.11 | 27.7 | 33.07 | 34.34 | 38.24 |
HT | UV | HT | UV | HT | UV | |||||||
VHR (After Aging) | 99.24% | 99.21% | 99.07% | 98.97% | 99.22% | 99.24% | 99.01% | 99.06% | 99.23% | 99.24% | 99.05% | 99.08% |
Ion Concentration (After Aging) | 50.95 | 46.99 | 71.92 | 78.09 | 53.01 | 49.98 | 61.98 | 66.91 | 48.22 | 47.88 | 50.23 | 55.67 |
Note: A total of 4 test cells were taken. Subsequently, two were tested after HT experiment, and two were tested after UV aging experiment. HT aging conditions: 150°C * 1h. UV aging conditions: 5000 mJ.
Conclusion: In mixed crystal products, the adsorption effect of SPA-MetSil modified silica gel is comparable to that of SiliaMets.
Contact Us Today to request a sample or discuss how Agesin® SPA-MetSil-SH can meet your high-purity requirements.
